2/8 Collaborative genomic studies of Tourette Disorder

This collaborative study unites an international group of expert clinicians specializing in Tourette Disorder (TD) with statistical and molecular geneticists. It is motivated by three central hypotheses:
1) that a key rate- limiting factor for TD gene discovery has been the paucity of publically available, large-scale biomaterial resources of the kind that are now commonplace for many neuropsychiatric disorders;
2) based on recent data from a host of other genetically complex disorders, a comprehensive genomics study of TD will require large samples sizes and should focus on the potential contribution of rare as well as common alleles and both sequence and structural variants; and
3) an increased understanding of the genetic etiology of TD will translate into novel and more effective approaches to treating this often-debilitating disorder, and consequently will have marked public health benefits.